💊 Chemical information

Factor I; Fibrinogène; Fibrinógeno; Fibrinogenum; Fibrinojen; Fibrynogen.
ATC — B02BB01; B02BC10.
ATC Vet — QB02BB01.


Many pharmacopoeias have monographs, including Eur..

Ph. Eur. 6.2

(Human Fibrinogen; Fibrinogenum Humanum). It contains the soluble constituent of human plasma that is transformed to fibrin on addition of thrombin. It is obtained from plasma for fractionation and the method of preparation includes a step or steps that have been shown to remove or inactivate known agents of infection. Stabilisers, including protein such as human albumin, salts, and buffers may be added. No antimicrobial preservative is added. When dissolved in the volume of solvent stated on the label, the solution contains not less than 10 g/litre of fibrinogen. A white or pale yellow hygroscopic powder or friable solid. Store in airtight containers. Protect from light.

💊 Profile

Fibrinogen has been used to control haemorrhage associated with low blood-fibrinogen concentration in afibrinogenaemia or hypofibrinogenaemia although plasma or cryoprecipitate is usually preferred. Fibrinogen has also been used in disseminated intravascular coagulation. It is a component of fibrin glue (see Fibrin, above). Recombinant human fibrinogen is under investigation. Fibrinogen labelled with radionuclides has also been used in diagnostic procedures.

💊 Preparations

Ph. Eur.: Fibrin Sealant Kit; Human Fibrinogen.

Proprietary Preparations

Austria: Haemocomplettan; Cz.: Haemocomplettan; Ger.: Haemocomplettan; Gr.: Haemocomplettan; Hung.: Haemocomplettan; Neth.: Haemocomplettan; Port.: Haemocomplettan; Switz.: Haemocomplettan; Thai.: Fibroraas. Multi-ingredient: Arg.: Beriplast P; Tissucol; Tissucol Duo Quick†; Austral.: Tisseel Duo; Austria: Beriplast; TachoComb; TachoSil; Tissucol; Tissucol Duo Quick; Belg.: Tissucol Duo; Braz.: Beriplast P; Tissucol†; Canad.: Tisseel; Chile: Beriplast P; Cz.: TachoComb†; TachoSil; Tissucol; Denm.: TachoSil; Tisseel Duo Quick; Fin.: TachoSil; Tisseel Duo Quick; Fr.: Beriplast; TachoSil; Tissucol; Ger.: Beriplast; Quixil; TachoComb†; TachoSil; Tissucol Duo S; Tissucol-Kit; Gr.: Beriplast P; Hong Kong: Beriplast P; TachoComb; Tisseel; Hung.: Beriplast P; TachoComb†; Tissucol-Kit; Indon.: Beriplast; Israel: Beriplast; Tisseel; Ital.: Beriplast; Quixil; TachoSil; Mex.: Beriplast P; Tissucol†; Neth.: Beriplast P; Quixil; TachoSil; Tissucol; Tissucol Duo; Norw.: TachoSil; Pol.: Beriplast; Port.: TachoSil; Tissucol Duo; Rus.: TachoComb (ТахоКомб); Spain: Beriplast P Combi; TachoSil; Tissucol Duo; Swed.: TachoSil; Tisseel Duo Quick; Switz.: Beriplast P; TachoSil; Tissucol; Tissucol Duo S; Thai.: Fibrin Glue†; TachoComb†; Turk.: Beriplast P; Tisseel VH; UK: TachoSil; Tisseel; USA: Artiss.
Published December 03, 2018.