Lormetazepam
(BAN, USAN, rINN)
Synonyms: Lormetatsepaami; Lormétazépam; Lormetazepamum; Wy4082. (RS)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy1-methyl-1,4-benzodiazepin-2-one.
Cyrillic synonym: Лорметазепам.
💊 Chemical information
Chemical formula: C16H12Cl2N2O2 = 335.2.
CAS — 848-75-9.
ATC — N05CD06.
ATC Vet — QN05CD06.
Pharmacopoeias.
In Br.BP 2008
(Lormetazepam). A white crystalline powder. Practically insoluble in water; soluble in alcohol and in methyl alcohol. Protect from light.💊 Dependence and Withdrawal
As for Diazepam.
◊ For the purpose of withdrawal regimens, 0.5 to 1 mg of lormetazepam is considered equivalent to about 5 mg of diazepam.
💊 Adverse Effects, Treatment, and Precautions
As for Diazepam.
💊 Interactions
As for Diazepam.
💊 Pharmacokinetics
Lormetazepam is rapidly absorbed from the gastrointestinal tract and metabolised to the inactive glucuronide. The terminal halflife is reported to be about 11 hours.
◊ A brief review of the pharmacokinetics of lormetazepam.1
1. Greenblatt DJ, et al. Clinical pharmacokinetics of the newer benzodiazepines. Clin Pharmacokinet 1983; 8: 233–52.
💊 Uses and Administration
Lormetazepam is a short-acting benzodiazepine with general properties similar to those of diazepam. It is mainly used as a hypnotic in the short-term management of insomnia in usual oral doses of 0.5 to 1.5 mg at night. A dose of 500 micrograms is recommended for elderly or debilitated patients. Lormetazepam is also used in some countries for premedication.
💊 Preparations
BP 2008: Lormetazepam Tablets.
Proprietary Preparations
Arg.: Dilamet†; Austria: Noctamid; Belg.: Doclormeta; Keladormet; Loramet; Loranka; Lormetamed; Metatop; Noctacalm; Noctamid; Octonox; Sedaben; Stilaze; Chile: Nocton; Denm.: Pronoctan; Fr.: Noctamide; Ger.: Ergocalm; Loretam; Noctamid; Gr.: Loramet; Hong Kong: Loramet†; Irl.: Noctamid; Ital.: Axilium; Ipnolor; Luzul; Mexylor; Minias; Neth.: Loramet†; Noctamid; NZ: Noctamid; Pol.: Noctofer; Port.: Noctamid†; S.Afr.: Loramet; Noctamid; Singapore: Loramet; Spain: Aldosomnil; Loramet; Noctamid; Switz.: Loramet; Noctamid; Thai.: Loramet†.Published January 15, 2019.