Lormetazepam

(BAN, USAN, rINN)
Lormetazepam Chemical formula
Synonyms: Lormetatsepaami; Lormétazépam; Lormetazepamum; Wy4082. (RS)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy1-methyl-1,4-benzodiazepin-2-one.
Cyrillic synonym: Лорметазепам.

💊 Chemical information

Chemical formula: C16H12Cl2N2O2 = 335.2.
CAS — 848-75-9.
ATC — N05CD06.
ATC Vet — QN05CD06.

Pharmacopoeias.

In Br.

BP 2008

(Lormetazepam). A white crystalline powder. Practically insoluble in water; soluble in alcohol and in methyl alcohol. Protect from light.

💊 Dependence and Withdrawal

As for Diazepam.

💊 Adverse Effects, Treatment, and Precautions

As for Diazepam.

💊 Interactions

As for Diazepam.

💊 Pharmacokinetics

Lormetazepam is rapidly absorbed from the gastrointestinal tract and metabolised to the inactive glucuronide. The terminal halflife is reported to be about 11 hours.
1. Greenblatt DJ, et al. Clinical pharmacokinetics of the newer benzodiazepines. Clin Pharmacokinet 1983; 8: 233–52.

💊 Uses and Administration

Lormetazepam is a short-acting benzodiazepine with general properties similar to those of diazepam. It is mainly used as a hypnotic in the short-term management of insomnia in usual oral doses of 0.5 to 1.5 mg at night. A dose of 500 micrograms is recommended for elderly or debilitated patients. Lormetazepam is also used in some countries for premedication.

💊 Preparations

BP 2008: Lormetazepam Tablets.

Proprietary Preparations

Arg.: Dilamet†; Austria: Noctamid; Belg.: Doclormeta; Keladormet; Loramet; Loranka; Lormetamed; Metatop; Noctacalm; Noctamid; Octonox; Sedaben; Stilaze; Chile: Nocton; Denm.: Pronoctan; Fr.: Noctamide; Ger.: Ergocalm; Loretam; Noctamid; Gr.: Loramet; Hong Kong: Loramet†; Irl.: Noctamid; Ital.: Axilium; Ipnolor; Luzul; Mexylor; Minias; Neth.: Loramet†; Noctamid; NZ: Noctamid; Pol.: Noctofer; Port.: Noctamid†; S.Afr.: Loramet; Noctamid; Singapore: Loramet; Spain: Aldosomnil; Loramet; Noctamid; Switz.: Loramet; Noctamid; Thai.: Loramet†.
Published January 15, 2019.