Fumagillin

(BAN, rINN)
Fumagillin Chemical formula
Synonyms: Fumagilina; Fumagilliini; Fumagilline; Fumagillinum. 4-(1,2-Epoxy1,6-dimethylhex-4-enyl)-5-methoxy-1-oxaspiro[2.5]oct-6-yl hydrogen deca-2,4,6,8-tetraenedioate.
Cyrillic synonym: Фумагиллин.

💊 Chemical information

Chemical formula: C26H34O7 = 458.5.
CAS — 23110-15-8.
ATC — P01AX10.
ATC Vet — QP51AX23.

💊 Profile

Fumagillin is an alicyclic antibiotic produced by certain strains of There have been several reports of successful treatment in individual patients using fumagillin topically,1-3 usually as a solution of bicyclohexylammonium fumagillin containing the equivalent of fumagillin 70 micrograms/mL. Oral fumagillin has been effective in the treatment of diarrhoea due to intestinal microsporidial infection with Enterocytozoon bieneusi in patients with HIV infection.4-7
1. Rosberger DF, et al. Successful treatment of microsporidial keratoconjunctivitis with topical fumagillin in a patient with AIDS. Cornea 1993; 12: 261–5
2. Diesenhouse MC, et al. Treatment of microsporidial keratoconjunctivitis with topical fumagillin. Am J Ophthalmol 1993; 115: 293–8
3. Garvey MJ, et al. Topical fumagillin in the treatment of microsporidial keratoconjunctivitis in AIDS. Ann Pharmacother 1995; 29: 872–4
4. Molina J-M, et al. Potential efficacy of fumagillin in intestinal microsporidiosis due to Enterocytozoon bieneusi in patients with HIV infection: results of a drug screening study. AIDS 1997; 11: 1603–10
5. Molina J-M, et al. Trial of oral fumagillin for the treatment of intestinal microsporidiosis in patients with HIV infection. AIDS 2000; 14: 1341–8
6. Molina J-M, et al. Fumagillin treatment of intestinal microsporidiosis. N Engl J Med 2002; 346: 1963–9
7. Abramowicz M, ed. Drugs for parasitic infections. 1st ed. New Rochelle NY: The Medical Letter, 2007.

💊 Preparations

Proprietary Preparations

Fr.: Flisint.
Published November 17, 2018.