Diloxanide Furoate

(BANM, rINNM)
Diloxanide Furoate Chemical formula
Synonyms: Diloksanid Furoat; Diloxanide, Furoate de; Diloxanidi Furoas; Furoato de diloxanida. 4-(N-Methyl-2,2-dichloroacetamido)phenyl 2-furoate.
Cyrillic synonym: Дилоксанида Фуроат.

💊 Chemical information

Chemical formula: C14H11Cl2NO4 = 328.1.
CAS — 579-38-4 (diloxanide); 3736-81-0 (diloxanide furoate).
ATC — P01AC01.

Pharmacopoeias.

In Br., Int., and US.

BP 2008

(Diloxanide Furoate). A white or almost white, odourless or almost odourless, crystalline powder. Very slightly soluble in water; slightly soluble in alcohol and in ether; freely soluble in chloroform. Protect from light.

USP 31

(Diloxanide Furoate). A white or almost white, crystalline powder. Very slightly soluble in water; slightly soluble in alcohol and in ether; freely soluble in chloroform. Store in airtight containers. Protect from light.

💊 Adverse Effects

Flatulence is the most common adverse effect during treatment with diloxanide furoate. Vomiting, pruritus, and urticaria may occasionally occur.

💊 Pharmacokinetics

Diloxanide furoate is hydrolysed before absorption from the gastrointestinal tract. The resulting diloxanide is readily absorbed and excreted mainly in the urine as the glucuronide; less than 10% of a dose appears in the faeces.

💊 Uses and Administration

Diloxanide furoate, a dichloroacetamide derivative, is a luminal amoebicide acting principally in the bowel lumen and is used in the treatment of intestinal amoebiasis. It is given alone in the treatment of asymptomatic cyst passers and with an amoebicide that acts in the tissues, such as metronidazole, in patients with invasive amoebiasis. Diloxanide furoate is given orally in a dosage of 500 mg three times daily for 10 days; children weighing more than 25 kg may be given 20 mg/kg daily, in 3 divided doses, for 10 days. The course of treatment may be repeated if necessary.

💊 Preparations

BP 2008: Diloxanide Tablets. Proprietary PreparationsMulti-ingredient: India: Aristogyl Plus; Dyrade-M; Entamizole; Entrolate†; Qugyl; Tinidafyl Plus; Wotinex.
Published November 05, 2018.