Synonyms: BT-436; Déhydroémétine, Chlorhydrate de; 2,3-Dehydroemetine Hydrochloride; Dehydroemetini Hydrochloridum; DHE; Hidrocloruro de dehidroemetina; Ro-1-9334. 2,3-Didehydro6′,7′,10,11-tetramethoxyemetan dihydrochloride; 3-Ethyl1,6,7,11b-tetrahydro-9,10-dimethoxy-2-(1,2,3,4-tetrahydro-6,7dimethoxy-1-isoquinolylmethyl)-4H-benzo[a]quinolizine dihydrochloride.
Cyrillic synonym: Дегидроэметина Гидрохлорид.
Chemical formula: C29H38N2O4,2HCl = 551.5.
CAS — 4914-30-1 (dehydroemetine); 2228-39-9 (dehydroemetine hydrochloride).
Dehydroemetine, a synthetic derivative of emetine, is a tissue amoebicide with similar actions and uses, although probably of a lower toxicity. Dehydroemetine should be avoided in patients with cardiac, renal, or neuromuscular disease and patients should be monitored for cardiac toxicity during treatment. When used in the treatment of amoebiasis, dehydroemetine hydrochloride is given by intramuscular injection in a dose of 1 mg/kg daily (maximum daily dose of 60 mg), generally for up to 4 to 6 days, but for no more than 5 days in children. A dose of 0.5 mg/kg has been suggested for elderly or severely ill patients. At least 6 weeks should elapse before treatment is repeated. Following treatment with dehydroemetine, all patients should receive a luminal amoebicide to eliminate organisms from the colon. Patients with hepatic amoebiasis may be given supplementary treatment with chloroquine.
Liver fluke infections.Dehydroemetine has been given1 in the treatment of the liver fluke infection fascioliasis.
1. Farid Z, et al. Treatment of acute toxaemic fascioliasis. Trans R Soc Trop Med Hyg 1988; 82: 299.
Published October 31, 2018.