Synonyms: Cloridrato de Profenamina; Ethopropazine Hydrochloride; Hidrocloruro de profenamina; Isothazine Hydrochloride; Profénamine, Chlorhydrate de; Profenamini Hydrochloridum; Prophenamini Chloridum. 10-(2-Diethylaminopropyl)phenothiazine hydrochloride.
Cyrillic synonym: Профенамина Гидрохлорид.
💊 Chemical information
Chemical formula: C19H24N2S,HCl = 348.9.
CAS — 522-00-9 (profenamine); 1094-08-2 (profenamine hydrochloride).
ATC — N04AA05.
ATC Vet — QN04AA05.
💊 Adverse Effects, Treatment, and Precautions
As for Atropine Sulfate. Profenamine may also cause muscle cramps, paraesthesia, and a sense of heaviness in the limbs, epigastric discomfort, and nausea. Profenamine is a phenothiazine derivative; adverse effects associated with phenothiazines may occur, especially with high doses.
Breast feeding.Profenamine is distributed into the milk of lactating mothers.1
1. Rowan JJ. Excretion of drugs in milk. Pharm J 1976; 217: 184–7.
As for antimuscarinics in general.
💊 Uses and Administration
Profenamine hydrochloride is a phenothiazine derivative with antimuscarinic, adrenergic-blocking, antihistaminic, local anaesthetic, and ganglion-blocking properties. It has been used in the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazines, but, like other antimuscarinics, is of no value against tardive dyskinesias. It has been used in a usual initial oral dose of 50 mg three times daily, gradually increased to 500 mg or more daily in divided doses, according to response.
Published November 22, 2018.