Metixene Hydrochloride

(BANM, rINNM)
Metixene Hydrochloride Chemical formula
Synonyms: Hidrocloruro de metixeno; Methixene Hydrochloride (USAN); Methixene Hydrochloride Monohydrate; Metikseenihydrokloridi; Metikseno hidrochloridas; Métixène, chlorhydrate de; Metixén-hidroklorid; Metixen-hydrochlorid monohydrát; Metixenhydroklorid; Metixeni hydrochloridum; Metixeni Hydrochloridum Monohydricum; NSC-78194; SJ-1977. (RS)-9-(1-Methyl-3piperidylmethyl)thioxanthene hydrochloride monohydrate.
Cyrillic synonym: Метиксена Гидрохлорид.

💊 Chemical information

Chemical formula: C20H23NS,HCl,H2O = 363.9.
CAS — 4969-02-2 (metixene); 1553-34-0 (anhydrous metixene hydrochloride); 7081-40-5 (metixene hydrochloride monohydrate).
ATC — N04AA03.
ATC Vet — QN04AA03.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Metixene Hydrochloride). A white or almost white, crystalline or fine crystalline powder. Soluble in water, in alcohol, and in dichloromethane. A 1.8% solution in water has a pH of 4.4 to 5.8. Protect from light.

💊 Profile

Metixene hydrochloride is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by drugs such as phenothiazines, but, like other antimuscarinics, is of no value against tardive dyskinesias. The usual oral dose of metixene hydrochloride is 2.5 mg three times daily initially, gradually increased according to response to a total of 15 to 60 mg daily in divided doses. Metixene hydrochloride has also been used in preparations to relieve gastrointestinal spasms.

💊 Preparations

Proprietary Preparations

Ger.: Tremarit; Hung.: Tremaril; Ital.: Tremaril; Swed.: Tremoquil†. Multi-ingredient: Philipp.: Spasmo-Canulase; Port.: Espasmo Canulase; S.Afr.: Spasmo-Canulase; Switz.: Spasmo-Canulase.
Published November 14, 2018.