Zinc Undecenoate

(USAN)
Synonyms: Cinko undecilenatas; Çinko Undesilenat; Cink-undecilenát; Sinkkiundesylenaatti; Undecilenato de zinc; Undecilinato de Zinco; Undecylenan zinečnatý; Zinc Undecylenate; Zinc, undécylénate de; Zinci undecylenas; Zinkundecylenat. Zinc di(undec-10enoate).
Cyrillic synonym: Ундециленат Цинка.

💊 Chemical information

Chemical formula: (C11H19O2)2Zn = 431.9.
CAS — 557-08-4.
ATC — D01AE04.
ATC Vet — QD01AE04.

Pharmacopoeias.

In Chin., Eur., and US.

Ph. Eur. 6.2

(Zinc Undecylenate; Zinc Undecenoate BP 2008). A fine white or almost white powder. Practically insoluble in water and in alcohol. Protect from light.

USP 31

(Zinc Undecylenate). A fine, white powder. Practically insoluble in water and in alcohol.

💊 Adverse Effects

Irritation may rarely occur after the topical application of undecenoic acid or its salts.

💊 Antimicrobial Action

Undecenoic acid and its derivatives are active against some pathogenic fungi, including the dermatophytes Epidermophyton, Trichophyton, and Microsporum spp.

💊 Uses and Administration

Undecenoic acid and its zinc salt are applied topically in the prophylaxis and treatment of superficial dermatophytoses, particularly tinea pedis. Typical concentrations are undecenoic acid 2 to 5% and zinc undecenoate 20%. They are used in creams, ointments, solutions, or powders, often with each other. Calcium undecenoate is used as a 10 or 15% powder. Several other salts and derivatives of undecenoic acid including methyl, phenyl, and propyl undecenoate, disodium sulfosuccinated undecenoic acid monoethanolamide, and undecenoic acid monoethanolamide and diethanolamide have been used similarly.
1. Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot. Available in The Cochrane Database of Systematic Reviews; Issu
3. Chichester: John Wiley; 2007 (accessed 07/07/08).

💊 Preparations

USP 31: Compound Undecylenic Acid Ointment.

Proprietary Preparations

Arg.: Bentophyto; Sinamida Pies; Umasam; Austria: Crino Cordes; Mayfung; Pelsana Med; Canad.: Desenex; Cz.: Mykoseptin; Fr.: Mycodecyl; Hung.: Lubex; Indon.: Decyline; Topix; Undecyl; Irl.: Caldesene; Desenex; Israel: Undecyl; Mex.: Derman; Pol.: Mykodermina; Unguentum Undecylenicum; Rus.: Mykoseptin (Микосептин); S.Afr.: Mycota; Switz.: Fungex; Lubex; Turexan Creme; Turexan Douche; Turk.: Undo-Pate; Utalk; UK: Mycota; USA: Blis-To-Sol; Caldesene; Cruex; Decylenes; Desenex; Elon Dual Defense; Protectol; Undelenic. Multi-ingredient: Arg.: Bacteroskin†; Bentophyto; Bifena; Champuacid; Cicatrol; Clevosan; Dettonjab; Farm-X; Fungicida†; Fungocop; Hipoglos Cicatrizante; Laurinol Plus; LB Jabon con Purcelin†; Novo Miconol; Novofarma Champu; Piecidex†; Plusderm†; Tersoderm Anticaspa†; Austral.: Mycoderm†; Pedoz; Sebitar; Seborrol†; Austria: Dequafungan; Mycopol; Pelsana Med; Salvyl; Braz.: Andriodermol; Micosan†; Micotox†; Micoz†; Chile: Fittig; Hansaplast Footcare†; Lady Fittig†; NP-27; Cz.: Hexadecyl†; Fr.: Paps; Ger.: Gehwol Fungizid†; Gehwol Nagelpilz†; Skinman Soft; Gr.: Ekzegamma†; Hong Kong: Acnederm; Fungifax†; Mycoderm†; Sebitar; Hung.: Squa-med; Indon.: Decyline; Mikorex; Skintex; Irl.: Ceanel†; Israel: Fungimon; Pedisol; Pitrisan; Ital.: Balta Intimo†; Foot Zeta; Genisol; Micofoot; Propast; Malaysia: Acnederm†; Sebitar; Mex.: Micotex; NZ: Acnederm†; Egomycol†; Grans Remedy; Sebitar; Seborrol†; Pol.: Undofen; Port.: Edoltar†; Micaveen; S.Afr.: AF; Mycota†; Singapore: Sebitar; Switz.: Crimanex; Ederphyt; Fungex; Pelsano; Pruri-med; Sebo Shampooing; Trosyd†; Turexan Emulsion†; Turk.: Fungecyl; Undo-Talk; UK: Ceanel; Healthy Feet; Monphytol†; Mycota; USA: Breezee Mist Foot Powder; Dermasept Antifungal; Gordochom; Phicon-F; Venez.: Diodonato†.
Published December 25, 2018.