Tolnaftate

(BAN, USAN, rINN)
Tolnaftate Chemical formula
Synonyms: Sch-10144; Tolnaftaatti; Tolnaftát; Tolnaftat; Tolnaftatas; Tolnaftato; Tolnaftatum. O-2-Naphthyl m,N-dimethylthiocarbanilate.
Cyrillic synonym: Тольнафтат.

💊 Chemical information

Chemical formula: C19H17NOS = 307.4.
CAS — 2398-96-1.
ATC — D01AE18.
ATC Vet — QD01AE18.

Pharmacopoeias.

In Eur., Jpn, and US.

Ph. Eur. 6.2

(Tolnaftate). A white or yellowish-white powder. Practically insoluble in water; very slightly soluble in alcohol; freely soluble in acetone and in dichloromethane. Protect from light.

USP 31

(Tolnaftate). A white to creamy-white, fine powder, with a slight odour. Practically insoluble in water; slightly soluble in alcohol; freely soluble in acetone and in chloroform; sparingly soluble in ether. Store in airtight containers.

💊 Adverse Effects

Skin reactions occur rarely with tolnaftate and include irritation and contact dermatitis.

💊 Antimicrobial Action

Tolnaftate inhibits the growth of the dermatophytes Epidermophyton, Microsporum, Trichophyton spp., and Malassezia furfur, but is not active against Candida spp. or bacteria.

💊 Uses and Administration

Tolnaftate is an antifungal used topically as a 1% gel, solution, powder, ointment, or cream in the treatment or prophylaxis of superficial dermatophyte infections and of pityriasis versicolor. Tolnaftate is applied twice daily for 2 to 6 weeks. Repeat treatment may be required.

💊 Preparations

USP 31: Tolnaftate Cream; Tolnaftate Gel; Tolnaftate Topical Aerosol; Tolnaftate Topical Powder; Tolnaftate Topical Solution.

Proprietary Preparations

Arg.: Athletes Foot†; Tinaderm†; Austral.: Antifungal Foot Deodorant†; Curatin; Ringworm Ointment; Tinaderm; Tineafax; Canad.: Absorbine Jr Antifungal; Footworks; Pitrex; Scholl Athlete’s Foot; Tinactin; ZeaSorb AF; Chile: Tinaderm; Fr.: Sporiline†; Ger.: Tinatox; Tonoftal; Hong Kong: Aftate; Hung.: Athletes Foot†; Chinofungin; Digifungin; India: Tinaderm; Tolnaderm; Indon.: Naftate; Irl.: Mycil; Tinaderm†; Israel: Athletes Foot; Pitrex; Tinasol; Ital.: Tinaderm†; Malaysia: Dermoplex Antifungal; MycoAid; Tinaderm†; Tolnaderm; Mex.: Excelsior†; Tinaderm; Tinoxal; NZ: Tinaderm†; Philipp.: Tinactin; Tolnaderm; Port.: Tinaderme; S.Afr.: Tinaderm; Singapore: Tinaderm†; Spain: Micoisdin†; Tinaderm; Thai.: EzonT; Tono; Tu rk.: Mikoderm; UK: Mycil; Scholl Athlete’s Foot; Tinaderm; USA: Aftate; Blis-To-Sol; Dr Scholl’s Athlete’s Foot; Genaspor; Lamisil AF Defense; Podactin; Quinsana Plus; Tinactin; Venez.: Tinaderm; Tolnaftan. Multi-ingredient: Arg.: Bacticort Complex; Cevaderm; Quadriderm†; Austral.: Mycil Healthy Feet; Braz.: Cremederme; Permut; Poliderms; Quadriderm; Quadrikin; Quadrilon; Quadriplus; Qualiderm; Tetraderm; Hong Kong: Alber T†; Dermafacte; Mycil; Quadriderm; Triditol-G; India: Fourderm; Quiss; Irl.: Mycil; Tinaderm-M; Israel: Phytoderm Compositum; Malaysia: Elan-Forte; Philipp.: Quadriderm; Quadrotopic; S.Afr.: Duoderm†; Quadriderm; Singapore: Quadriderm†; Spain: Cuatroderm; Switz.: Quadriderm; Thai.: Alber T; Ezon-T; UK: Mycil; Tinaderm-M; USA: Absorbine Athletes Foot Care; Dermasept Antifungal.
Published December 22, 2018.