Mepartricin

(BAN, USAN, rINN)
Mepartricin Chemical formula
Synonyms: Mepartricina; Mépartricine; Mepartricinum; Methylpartricin; SN654; SPA-S-160.
Cyrillic synonym: Мепартрицин.

💊 Chemical information

CAS — 11121-32-7.
ATC — A01AB16; D01AA06; G01AA09; G04CX03. ATC Vet — QA01AB16; QD01AA06; QG01AA09; QG04CX03.

💊 Profile

Mepartricin is a mixture of the methyl esters of 2 related polyene antibiotics that may be obtained from a strain of Streptomyces aureofaciens. It has antifungal and antiprotozoal activity and has been used in vaginal candidiasis and trichomoniasis as pessaries or as a vaginal cream. A cream is also available for the treatment of superficial candidiasis. An oral form of mepartricin sodium laurilsulfate is also used. Oral mepartricin 40 mg daily is used in the treatment of some prostate disorders.

Prostate disorders.

Studies1,2 have shown that mepartricin given by mouth is effective in the treatment of benign prostatic hyperplasia; a dose of 40 mg daily is commonly used.2 Mepartricin is thought to reduce cholesterol, oestrogen, and androgen binding to the prostate. Similarly, another study3 has shown that the same dose of mepartricin provides symptomatic improvement in the management of chronic prostatitis/chronic pelvic pain syndrome.
1. Tosto A, et al. A double-blind study of the effects of mepartricin in the treatment of obstruction due to benign prostatic hyperplasia. Curr Ther Res 1995; 56: 1270–75
2. Denis L, et al. Double-blind, placebo-controlled trial to assess the efficacy and tolerability of mepartricin in the treatment of BPH. Prostate 1998; 37: 246–52
3. De Rose AF, et al. Role of mepartricin in category III chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a randomized prospective placebo-controlled trial. Urology 2004; 63: 13–16.

💊 Preparations

Proprietary Preparations

Austria: Iperplasin; Prostec; Belg.: Tricandil†; Braz.: Montricin†; Chile: Normoprost†; Cz.: Ipertrofan; Ital.: Ipertrofan; Tricandil; Philipp.: Ipertrofan; Pol.: Ipertrofan; Port.: Iperplasin; Ipertrofan; Tricandil. Multi-ingredient: Braz.: Tricangine†.
Published November 29, 2018.