Fenticonazole Nitrate

(BANM, USAN, rINNM)
Fenticonazole Nitrate Chemical formula
Synonyms: Fenticonazole, nitrate de; Fenticonazoli nitras; Fentikonatsolinitraatti; Fentikonazolnitrat; Fentikonazol-nitrát; Fentikonazolo nitratas; Nitrato de fenticonazol; Rec-15/1476. (±)-1-[2,4-Dichlorotrate.
Cyrillic synonym: Фентиконазола Нитрат.

💊 Chemical information

Chemical formula: C24H20Cl2N2OS,HNO3 = 518.4.
CAS — 72479-26-6 (fenticonazole); 73151-29-8 (fenticonazole nitrate).
ATC — D01AC12; G01AF12.
ATC Vet — QD01AC12; QG01AF12.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Fenticonazole Nitrate). A white or almost white, crystalline powder. Practically insoluble in water; sparingly soluble in dehydrated alcohol; freely soluble in dimethylformamide and in methyl alcohol. Protect from light.

💊 Adverse Effects and Precautions

Burning and itching have been reported after the application of fenticonazole nitrate. Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local application. For a discussion of the caution needed when using azole antifungals during pregnancy, see under Pregnancy in Precautions of Fluconazole.

💊 Antimicrobial Action

Fenticonazole is an imidazole antifungal active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans.

💊 Uses and Administration

Fenticonazole is an imidazole antifungal used locally as the nitrate in the treatment of vulvovaginal candidiasis. A 200mg pessary is inserted into the vagina at bedtime for 3 nights or a 600-mg pessary is inserted once only at bedtime. Fenticonazole nitrate is also applied topically as a 2% cream or solution for the treatment of fungal skin infections.

💊 Preparations

Proprietary Preparations

Arg.: Lomexin†; Austria: Lomexin; Braz.: Fentizol; Lomexin; Cz.: Lomexin; Fr.: Lomexin; Terlomexin; Ger.: Fenizolan; Lomexin; Gr.: Lomexin; Hung.: Gynoxin; Ital.: Falvin; Fentiderm†; Fentigyn†; Lomexin; Mex.: Lomexin; Neth.: Gynoxin; Pol.: Gynoxin; Port.: Lomexin; S.Afr.: Lomexin†; Singapore: Lomexin†; Spain: Laurimic; Lomexin; Micofulvin; Switz.: Mycodermil; Turk.: Gyno-Lomexin; UK: Lomexin†; Venez.: Mycofentin.
Published November 15, 2018.