Ciclopirox Olamine

(BANM, USAN, rINNM)
Synonyms: Ciclopirox olamina; Ciclopirox olaminum; Ciclopiroxi Olaminum; Ciclopiroxolamine; Ciclopiroxum Olaminum; Ciklopiroksas olaminas; Ciklopirox olamin; Ciklopiroxolamin; Ciklopiroxolamin; Hoe-296; Siklopiroksiolamiini; Sikloproks Olamin. The 2aminoethanol salt of 6-Cyclohexyl-1-hydroxy-4-methyl-2-pyridone.
Cyrillic synonym: Циклопирокс Оламин.

💊 Chemical information

Chemical formula: C12H17NO2,C2H7NO = 268.4.
CAS — 41621-49-2.
ATC — D01AE14; G01AX12.
ATC Vet — QD01AE14; QG01AX12.

Pharmacopoeias.

In Chin., Eur., and US.

Ph. Eur. 6.2

(Ciclopirox Olamine). A white or pale yellow crystalline powder. It exhibits polymorphism. Slightly soluble in water; very soluble in alcohol and in dichloromethane; slightly soluble in ethyl acetate; practically insoluble in cyclohexane. A 1% solution in water has a pH of 8.0 to 9.0. Protect from light.

USP 31

(Ciclopirox Olamine). A white to slightly yellowishwhite, crystalline powder. Slightly soluble in water; very soluble in alcohol and in dichloromethane; practically insoluble in cyclohexane. pH of a 1% solution in water is between 8.0 and 9.0. Store in airtight containers at a temperature of 5° to 25°. Protect from light.

💊 Adverse Effects

Irritation and pruritus have been reported after topical application of ciclopirox.

💊 Antimicrobial Action

Ciclopirox has a wide spectrum of antifungal activity. It inhibits most Candida, Epidermophyton, Microsporum, and Trichophyton spp. and is also active against Malassezia furfur. It has some antibacterial activity.

💊 Uses and Administration

Ciclopirox is an antifungal that is applied topically in the treatment of fungal skin and nail infections, including cutaneous candidiasis, dermatophytosis, pityriasis versicolor, and seborrhoeic dermatitis. It has also been used in the treatment of vaginal candidiasis. It is applied twice daily for skin infections, as a cream, gel, suspension, solution, or powder; both the base and the olamine salt have been used, with products containing the equivalent of 0.77% ciclopirox base. A lacquer containing 8% ciclopirox base is applied once daily for nail infections. A shampoo containing 1% ciclopirox base is used twice weekly for the treatment of seborrhoeic dermatitis.
1. Gupta AK, Skinner AR. Ciclopirox for the treatment of superficial fungal infections: a review. Int J Dermatol 2003; 42 (suppl 1): 3–9
2. Gupta AK, Nicol KA. Ciclopirox 1% shampoo for the treatment of seborrheic dermatitis. Int J Dermatol 2006; 45: 66–9.

💊 Preparations

USP 31: Ciclopirox Olamine Cream; Ciclopirox Olamine Topical Suspension.

Proprietary Preparations

Arg.: Dermaflor†; Loprox; Micopirox; Stieprox; Austral.: Stieprox; Austria: Batrafen; Stieprox; Braz.: Fungirox†; Gino Loprox; Loprox; Micolamina; Micoliv†; Stiprox; Canad.: Loprox; Penlac; Stieprox; Chile: Batrafen; Fungopirox; Mikium†; Stiprox; Cz.: Batrafen; Dafnegin; Stieprox; Denm.: Mycofen; Stieprox; Fin.: Stieprox; Fr.: Mycosquam; Mycoster; Sebiprox; Stiprox; Ger.: Batrafen; Ciclopoli; Inimur Myko; Nagel Batrafen; Sebiprox; Gr.: Candimyc; Dafnegin†; Myclopir; Mycomycen; Neo-botacreme; Neo-mycodermol; Rozolam; Stieprox; Hong Kong: Batrafen; Stieprox; Hung.: Batrafen; India: Olamin; Onylac; Indon.: Batrafen; Loprox; Irl.: Batrafen†; Oilatum Scalp Treatment; Stieprox; Israel: Batrafen; Cicloderm; Ital.: Batrafen; Biroxol†; Brumixol; Dafnegin; Miclast; Micomicen; Micoxolamina; Sebiprox; Stiprox; Malaysia: Stieprox; Mex.: Loprox; Stiprox; Neth.: Loprox; Sebiprox; Norw.: Stieprox; NZ: Batrafen; Stieprox; Philipp.: Stieprox; Pol.: Batrafen; Dafnegin; Hascofungin; Pirolam; Stieprox; Port.: Batrafen; Mycoster; Sebiprox; Rus.: Batrafen (Батрафен); Singapore: Stieprox; Spain: Batrafen; Ciclochem; Fungowas; Rimafungol†; Sebiprox; Switz.: Batrafen; Dafnegil Neo; Thai.: Cicloderm†; Loprox; Stieprox; Turk.: Canolen; Nibulen; UK: Oilatum Scalp Treatment; USA: Loprox; Penlac; Venez.: Batrafen. Multi-ingredient: Arg.: Derm’s Shampoo; Stieproxal; Fr.: Novophane; Novophane S; Stiproxal; India: Flucort-C; Israel: Cicloderm-C; UK: Oilatum Scalp Intensive.
Published October 30, 2018.