Muraglitazar

(USAN, rINN)
Muraglitazar Chemical formula
Synonyms: BMS-298585; Muraglitazarum. {[(4-Methoxyphenoxy)carbonyl]{4-[2-(5-methyl-2-phenyl-1,3oxazol-4-yl)ethoxy]benzyl}amino}acetic acid.
Cyrillic synonym: Мураглитазар.

Chemical information

Chemical formula: C29H28N2O7 = 516.5.
CAS — 331741-94-7.

Profile

Muraglitazar is a dual alfa/gamma peroxisome proliferatoractivated receptor (PPAR) activator. It has been investigated in the treatment of type 2 diabetes mellitus.

Adverse effects.

A review of data from 5 studies suggested that muraglitazar may be associated with an increased risk of adverse cardiovascular events and heart failure.1
1. Nissen SE, et al. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA 2005; 294: 2581–6.
Published November 16, 2018.