Acetohexamide

(BAN, USAN, rINN)
Acetohexamide Chemical formula
Synonyms: Acetohexamid; Acetohexamida; Acétohexamide; Acetohexamidum; Asetoheksamidi; Compound 33006. 1-(4-Acetylbenzenesulphonyl)-3-cyclohexylurea.
Cyrillic synonym: Ацетогексамид.

💊 Chemical information

Chemical formula: C15H20N2O4S = 324.4.
CAS — 968-81-0.
ATC — A10BB31.
ATC Vet — QA10BB31.

Pharmacopoeias.

In Jpn and US.

USP 31

(Acetohexamide). A white, practically odourless, crystalline powder. Practically insoluble in water and in ether; soluble 1 in 230 of alcohol and 1 in 210 of chloroform; soluble in pyridine and in dilute solutions of alkali hydroxides.

💊 Profile

Acetohexamide is a sulfonylurea antidiabetic. Its duration of action is 12 hours or more. It has been given orally in the treatment of type 2 diabetes mellitus in a usual initial dose of 250 mg daily before breakfast. The daily dose may then be increased by 250 to 500 mg at intervals of 5 to 7 days, to a maintenance dose of up to 1.5 g daily; increasing the dose above 1.5 g does not usually lead to further benefit. Doses in excess of 1 g daily may be taken in 2 divided doses, before the morning and evening meals.

💊 Preparations

USP 31: Acetohexamide Tablets.

Proprietary Preparations

USA: Dymelor†.
Published October 10, 2018.