Tilmicosin Phosphate

Synonyms: Fosfato de tilmicosina; Tilmicosine, Phosphate de; Tilmicosini Phosphas.
Cyrillic synonym: Тильмикозина Фосфат.

Chemical information

Chemical formula: C46H80N2O13,H3O4P = 967.1.
CAS — 137330-13-3.


Tilmicosin is a macrolide antibacterial used as the base or the phosphate in veterinary medicine.

Adverse effects.

Accidental self-injection of tilmicosin by a farm worker, resulting in asthenia and temporary pulmonary, gastrointestinal, and neuromuscular toxicity has been reported.1A review2 of human exposures to tilmicosin injection reported between March 1992 and March 2005 suggested that the overall risk of serious adverse effects was about 2 cases per million doses. Serious cardiovascular adverse effects, including bradycardia, hypertension, hypotension, tachycardia, and tachypnoea, occurred in 156 of 3168 reported cases and, of these, fatalities occurred in 13.
1. Crown LA, Smith RB. Accidental veterinary antibiotic injection into a farm worker. Tenn Med 1999; 92: 339–40
2. Veenhuizen MF, et al. Analysis of reports of human exposure to Micotil 300 (tilmicosin injection). J Am Vet Med Assoc 2006; 229: 1737–42.


Contact with tilmicosin should be avoided. It is irritating to the eyes and may cause allergic reactions.
Published May 08, 2019.