Tazobactam Sodium

(BANM, USAN, rINNM)
Tazobactam Sodium Chemical formula
Synonyms: CL-307579; CL-298741 (tazobactam); Natrii Tazobactamum; Tazobactam sódico; Tazobactam sodique; Tazobactamum natricum; Tazobaktam Sodyum; YTR830; YTR-830H (tazobactam). Sodium (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylate 4,4-dioxide.
Cyrillic synonym: Натрий Тазобактам.

💊 Chemical information

Chemical formula: C10H11N4NaO5S = 322.3.
CAS — 89786-04-9 (tazobactam); 89785-84-2 (tazobactam sodium).
ATC — J01CG02.
ATC Vet — QJ01CG02.

💊 Profile

Tazobactam is a penicillanic acid sulfone derivative with betalactamase inhibitory properties similar to those of sulbactam although it is regarded as more potent. It has the potential to enhance the activity of beta-lactam antibacterials against betalactamase-producing bacteria. Tazobactam sodium is given intravenously with piperacillin sodium for the treatment of bacterial infections. The pharmacokinetics of tazobactam and piperacillin are similar.
1. Bush K, et al. Kinetic interactions of tazobactam with β-lactamases from all major structural classes. Antimicrob Agents Chemother 1993; 37: 851–8
2. Payne DJ, et al. Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important β-lactamases. Antimicrob Agents Chemother 1994; 38: 767–72
3. Lee NLS, et al. β-Lactam antibiotic and β-lactamase inhibitor combinations. JAMA 2001; 285: 386–8.

💊 Preparations

Proprietary Preparations

Gr.: Zobactam; Zoracilin. Multi-ingredient: Arg.: Pipetexina; Tazonam; Austral.: Ta z oc in; Austria: Ta z o n a m ; Belg.: Ta zo c i n ; Braz.: Tazocin; Tazoxil†; Tazpen†; Canad.: Ta z o c in; Chile: Ta zo nam ; Cz.: Ta z oc i n ; Denm.: Ta z o c i n ; Fin.: Ta z o c i n ; Fr.: Ta z o cilline; Ger.: Tazobac; Gr.: Bactalin; Gramenox; Oliten; Tazepen; Tazidron; Tazobion; Tazocin; Tazorex; Hong Kong: Ta zo ci n; Hung.: Ta zo ci n ; India: Dibact†; Tazact; Tazofast; Tazopen; Zosyn; Indon.: Ta z o c i n ; Irl.: Taz o ci n; Israel: Ta z o c i n ; Ital.: Tazobac; Tazocin; Malaysia: Ta z o c i n ; Mex.: Tasovak; Ta z o c i n ; Neth.: Ta zo ci n; Norw.: Ta z o c i n ; NZ: Ta zo ci n; Philipp.: Ta z o c i n ; Pol.: Ta z o c i n ; Port.: Ta z o b a c ; S.Afr.: Taz o b a x ; Ta z oc in ; Singapore: Ta z o c in; Spain: Ta z o c e l ; Swed.: Ta zo ci n; Switz.: Ta z o b a c ; Thai.: Ta z o c i n ; Tur k.: Ta z o c i n ; UK: Tazo ci n ; USA: Zosyn; Venez.: Tazo pr i l; Ta z p e n .
Published May 08, 2019.