Sulfametopyrazine

(BAN)
Sulfametopyrazine Chemical formula
Synonyms: Sulfalene (USAN, pINN); AS-18908; NSC-110433; Solfametopirazina; Solfametossipirazina; Sulfaleeni; Sulfalen; Sulfalène; Sulfaleno; Sulfalenum; Sulfamethoxypyrazine; Sulfapirazinmetossina; Sulfapyrazin Methoxyne; Sulphalene. N 1 -(3-Methoxypyrazin-2yl)sulphanilamide.
Cyrillic synonym: Сульфален.

💊 Chemical information

Chemical formula: C11H12N4O3S = 280.3.
CAS — 152-47-6.
ATC — J01ED02.

Pharmacopoeias.

In It.

💊 Adverse Effects, Treatment, and Precautions

As for Sulfamethoxazole. If adverse effects occur, sulfametopyrazine has the disadvantage that several days are required for its elimination from the body.

💊 Interactions

💊 Antimicrobial Action

💊 Pharmacokinetics

Sulfametopyrazine is readily absorbed from the gastrointestinal tract; 60 to 80% is bound to plasma proteins. Only about 5% of a dose is metabolised to the acetyl derivative. It is slowly excreted in the urine. The biological half-life has been reported to be about 60 to 65 hours.

💊 Uses and Administration

Sulfametopyrazine is a long-acting sulfonamide that has been used orally in the treatment of respiratory- and urinary-tract infections due to sensitive organisms. Sulfametopyrazine is given with pyrimethamine in the treatment of malaria. It has also been given in the ratio 4 parts of sulfametopyrazine to 5 parts of trimethoprim as a combination with uses similar to those of co-trimoxazole.

💊 Preparations

Proprietary Preparations

Ger.: Longum†. Multi-ingredient: Belg.: Co-Arinate; Dafrafin; Ital.: Metakelfin; Mex.: Kelfiprim†.
Published May 08, 2019.