Sisomicin Sulfate

Synonyms: Antibiotic 6640 (sisomicin); Rickamicin Sulphate; Sch-13475 (sisomicin); Sisomicin Sulphate omicini Sulfas; Sissomicin Sulphate; Sulfato de sisomicina. 4O[(2R,3R)cis-3-Amino-6-aminomethyl-3,4-dihydro-2H-pyran-2yl]-2-deoxy-6O-(3-deoxy-4C-methyl-3-methylaminoinopyranosyl)streptamine sulphate; 2-Deoxy-6O-(3-deoxy-4Cmethyl-3-methylamino2,3,4,6-tetradeoxysulphate.
Cyrillic synonym: Сизомицина Сульфат.

💊 Chemical information

Chemical formula: (C19H37N5O7)2,5H2SO4 = 1385.4.
CAS — 32385-11-8 (sisomicin); 53179-09-2 (sisomicin sulfate).
ATC — J0 1 GB08.
ATC Vet — QJ01GB08.


In Chin., Jpn, and US.

USP 31

(Sisomicin Sulfate). It loses not more than 15% of its weight on drying. 1 mg of sisomicin sulfate has a potency equivalent to not less than 580 micrograms of sisomicin calculated on the dried basis. A 4% solution in water of sisomicin has a pH of 3.5 to 5.5. Store in airtight containers.

💊 Profile

Sisomicin, an antibiotic produced by Micromonospora inyoensis and closely related to gentamicin C1A, is an aminoglycoside with general properties similar to those of gentamicin. It is given as the sulfate but doses are expressed in terms of the base; 1.5 g of sisomicin sulfate is equivalent to about 1 g of sisomicin. The usual dose for adults is 3 mg/kg daily given intramuscularly in 2 or 3 divided doses. It may be given by intravenous infusion if necessary.

💊 Preparations

USP 31: Sisomicin Sulfate Injection.

Proprietary Preparations

India: Sisoptin; Ital.: Mensiso†.
Published May 08, 2019.