Rifamycin Sodium

(BANM, rINNM)
Rifamycin Sodium Chemical formula
Synonyms: M-14 (rifamycin); Natrii Rifamycinum; Rifamicina sódica; Rifamicin-nátrium; Rifamicino natrio druska; Rifamycin sodná sůl; Rifamycin SV Sodium; Rifamycine sodique; Rifamycinnatrium; Rifamycinum natricum; Rifamysiininatrium; Ryfamycinum Natricum; Ryfamycyna sodowa. Sodium (12Z,14E,24E)-(2S,16S,17S,18R,19R,20R,21S,22R,23S)-21-acetoxy-1,2-dihydro-6,9,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo2,7-(epoxypentadeca-1,11,13trienimino)-naphtho-[2,1b]furan5-olate.
Cyrillic synonym: Натрий Рифамицин.

💊 Chemical information

Chemical formula: C37H46NNaO12 = 719.8.
CAS — 6998-60-3 (rifamycin); 14897-39-3 (rifamycin sodium); 15105-92-7 (rifamycin sodium).
ATC — J04AB03; S01AA16; S02AA12. ATC Vet — QJ04AB03; QS01AA16; QS02AA12.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Rifamycin Sodium). The monosodium salt of rifamycin SV, a substance obtained by chemical transformation of rifamycin B which is produced during growth of certain strains of Amycolatopsis mediterranei. Rifamycin SV may also be obtained directly from certain mutants of A. mediterranei. The potency is not less than 900 units/mg calculated with reference to the anhydrous substance. A red, fine or slightly granular powder. Soluble in water; freely soluble in dehydrated alcohol. A 5% solution in water has a pH of 6.5 to 8.0. Store in airtight containers at a temperature of 2° to 8°. Protect from light.

💊 Adverse Effects and Precautions

Some gastrointestinal adverse effects have occurred after injections of rifamycin. High doses may produce alterations in liver function. Hypersensitivity reactions including rashes, pruritus, and anaphylaxis have occurred rarely, but prolonged use increases the risk of sensitisation. A reddish coloration of the urine and other body fluids has been reported. Rifamycin should be used with care in patients with hepatic dysfunction.

💊 Antimicrobial Action

Rifamycin has similar antimicrobial actions to those of rifampicin.

💊 Pharmacokinetics

Rifamycin is not effectively absorbed from the gastrointestinal tract. Plasma concentrations of 2 micrograms/mL have been achieved 2 hours after a dose of 250 mg by intramuscular injection; concentrations of about 11 micrograms/mL have been achieved 2 hours after an intravenous dose of 500 mg. Rifamycin is about 80% bound to plasma proteins and has a plasma half-life of about 1 hour. Rifamycin is excreted mainly in the bile and only small amounts appear in the urine.

💊 Uses and Administration

Rifamycin is a rifamycin antibacterial that has been used in the treatment of infections caused by susceptible organisms including Gram-positive organisms such as staphylococci. It has been given as the sodium salt by intramuscular injection and by slow intravenous infusion and is also given by local instillation and topical application.

💊 Preparations

Proprietary Preparations

Arg.: Plusderm ATB†; Rifocina; Austria: Rifocin; Belg.: Rifocine; Braz.: Rifan; Rifocina; Fr.: Otofa; Ital.: Rifocin; Mex.: Rifocyna; Port.: Rifocina; Rus.: Otofa (Отофа); Switz.: Otofa; Turk.: Rif; Rifocin; Venez.: Rifocina. Multi-ingredient: Braz.: Rifocort.
Published May 08, 2019.