Pipemidic Acid

(BAN, rINN)
Pipemidic Acid Chemical formula
Synonyms: Acide Pipémidique; Ácido pipemídico; Acidum Pipemidicum; Acidum pipemidicum trihydricum; Kyselina pipemidová trihydrát; Pipemidihappo; Pipemidiinihappotrihydraatti; Pipemidinsav-trihidrát; Pipemidinsyratrihydrat; Pipémidique (acide) trihydraté; Pipemido ru _ gštistrihidratas; Pipemidsyra; Piperamic Acid; 1489RB. 8-Ethyl-5,8-dihydro-5-oxo-2-(piperazin-1-yl)pyrido[2,3d]pyrimidine-6-carboxylic acid.
Cyrillic synonym: Пипемидовая Кислота.

💊 Chemical information

Chemical formula: C14H17N5O3 = 303.3.
CAS — 51940-44-4 (anhydrous pipemidic acid); 7257182-5 (pipemidic acid trihydrate).
ATC — J01MB04.
ATC Vet — QJ01MB04.

Pharmacopoeias.

In Chin., Eur., and Jpn (all as the trihydrate).

Ph. Eur. 6.2

(Pipemidic Acid Trihydrate). A pale yellow or yellow crystalline powder. Very slightly soluble in water. It dissolves in dilute solutions of acids and of alkali hydroxides. Protect from light.

💊 Profile

Pipemidic acid is a 4-quinolone antibacterial with properties similar to those of nalidixic acid, but is more active in vitro against some bacteria, including Pseudomonas aeruginosa. It is used (as the trihydrate) in the treatment of urinary-tract infections in oral doses equivalent to 400 mg of the anhydrous substance twice daily.

Interactions.

For the effect of pipemidic acid on the clearance of xanthines, see under Caffeine, and Theophylline.

Porphyria.

Pipemidic acid is considered to be unsafe in patients with porphyria because it has been shown to be porphyrinogenic in in-vitro systems.

💊 Preparations

Proprietary Preparations

Arg.: Finuret; Memento; Priper; Austria: Deblaston; Braz.: Balurol; Elofuran; Pipram; Pipurol; Uroxina; Chile: Nupra†; Purid; Uropimide; Fr.: Pipram; Ger.: Deblaston; Hong Kong: Urotractin; Indon.: Impresial; Urinter; Urixin; Urotractin; Utrex; Ital.: Acipem†; Biosoviran; Cistomid; Diperpen; Faremid; Filtrax†; Pipeacid†; Pipedac; Pipefort; Pipemid; Pipram; Pipurin; Urodene; Uropimid; Urosan; Urosetic; Urotractin; Jpn: Dolcol; Malaysia: Urixin†; Urotractin†; Mex.: Uribac†; Uriken†; Uripiser; Uronovag; Uropipemid; Neth.: Pipram; Philipp.: Urixin; Pol.: Palin; Urolin; Rus.: Palin (Палин); Pimidel (Пимидель); S.Afr.: Deblaston; Septidron†; Singapore: Urotractin; Spain: Galusan; Nuril; Urisan; Uropipedil; Thai.: Pipedic†; Urotractin. Multi-ingredient: Arg.: Priper Plus.
Published May 08, 2019.