Oritavancin

(rINN)
Synonyms: LY-333328; Oritavancina; Oritavancine; Oritavancinum. (4″R)22O-(3-Amino-2,3,6-trideoxy-3C-methylopyranosyl)N 3″ -[p-(p-chlorophenyl)benzyl]vancomycin.
Cyrillic synonym: Оритаванцин.

Chemical information

Chemical formula: C86H97Cl3N10O26 = 1793.1.
CAS — 171099-57-3 (oritavancin); 192564-14-0 (oritavancin phosphate).
NOTE. Oritavancin phosphate is USAN.

Profile

Oritavancin is a glycopeptide antibacterial under investigation for the treatment of complicated infections of the skin and soft tissues due to Gram-positive bacteria.
1. Van Bambeke F, et al. Glycopeptide antibiotics: from conventional molecules to new derivatives. Drugs 2004; 64: 913–36
2. Ward KE, et al. Oritavancin—an investigational glycopeptide antibiotic. Expert Opin Invest Drugs 2006; 15: 417–29
3. Poulakou G, Giamarellou H. Oritavancin: a new promising agent in the treatment of infections due to Gram-positive pathogens. Expert Opin Invest Drugs 2008; 17: 225–43
4. Crandon J, Nicolau DP. Oritavancin: a potential weapon in the battle against serious Gram-positive pathogens. Future Microbiol 2008; 3: 251–63.
Published May 08, 2019.