Synonyms: Metacycline Hydrochloride (pINNM); Hidrocloruro de metaciclina; Métacycline, Chlorhydrate de; Metacyclini Chloridum; Metacyclini Hydrochloridum; Metacykliny chlorowodorek; Méthylènecycline Chlorhydrate; 6-Methyleneoxytetracycline Hydrochloride.
Cyrillic synonym: Метациклина Гидрохлорид.
💊 Chemical information
Chemical formula: C22H22N2O8,HCl = 478.9.
CAS — 3963-95-9.
ATC — J01AA05.
ATC Vet — QJ01AA05.
Pharmacopoeias.In Chin., Pol., and US.
USP 31(Methacycline Hydrochloride). A yellow to dark yellow crystalline powder. Soluble 1 in 100 of water, 1 in 300 of alcohol, and 1 in 25 of 0.1N sodium hydroxide; very slightly soluble in chloroform and in ether. pH of a solution in water containing the equivalent of methacycline 1% is between 2.0 and 3.0. Store in airtight containers. Protect from light.
Methacycline is a tetracycline derivative with uses similar to those of tetracycline. Like demeclocycline, it is excreted more slowly than tetracycline and effective blood concentrations are maintained for longer periods; the plasma elimination halflife is about 14 hours. Methacycline hydrochloride is given orally in a usual adult dose of 600 mg daily in 2 divided doses, preferably 1 hour before or 2 hours after meals.
USP 31: Methacycline Hydrochloride Capsules; Methacycline Hydrochloride Oral Suspension.
Proprietary PreparationsFr.: Lysocline; Physiomycine; Ital.: Esarondil; Rotilen; Stafilon.
Published April 28, 2019.