Gramicidin Chemical formula
Synonyms: Gramicidin D; Gramicidin (Dubos); Gramicidina; Gramicidinas; Gramicidine; Gramicidinum; Gramisidiini; Gramisidin.
Cyrillic synonym: Грамицидин.

💊 Chemical information

CAS — 1405-97-6.
ATC — R02AB30.
ATC Vet — QR0 2AB30.


In Eur., Jpn, and US.

Ph. Eur. 6.2

(Gramicidin). It consists of a family of antimicrobial linear polypeptides usually obtained by extraction from tyrothricin, the complex isolated from the fermentation broth of Bacillus brevis. The main component is gramicidin A1, together with gramicidins A2, B1, C1, and C2 in particular. The potency is not less than 900 units/mg calculated with reference to the dried substance. A white or almost white, slightly hygroscopic, crystalline powder. Practically insoluble in water; sparingly soluble in alcohol; soluble in methyl alcohol. Store in airtight containers. Protect from light.

USP 31

(Gramicidin). An antibacterial substance produced by the growth of Bacillus brevis (Bacillaceae); it may be obtained from tyrothricin. It has a potency of not less than 900 micrograms of gramicidin per mg, calculated on the dried basis. A white or practically white, odourless, crystalline, powder. Insoluble in water; soluble in alcohol. Store in airtight containers.

💊 Profile

Gramicidin has properties similar to those of tyrothricin and is too toxic to be given systemically. It is used topically for the local treatment of susceptible infections usually with other antibacterials such as neomycin and polymyxin B, and often with a corticosteroid as well.

💊 Preparations

USP 31: Neomycin and Polymyxin B Sulfates and Gramicidin Cream; Neomycin and Polymyxin B Sulfates and Gramicidin Ophthalmic Solution; Neomycin and Polymyxin B Sulfates, Gramicidin, and Hydrocortisone Acetate Cream; Neomycin Sulfate and Gramicidin Ointment; Nystatin, Neomycin Sulfate, Gramicidin, and Triamcinolone Acetonide Cream; Nystatin, Neomycin Sulfate, Gramicidin, and Triamcinolone Acetonide Ointment. Proprietary PreparationsMulti-ingredient: Arg.: Antibiocort†; Aseptobron N; Biotaer Nasal; Bucoangin N; Caext; Carnot Colutorio; Desenfriol Caramelos†; Gargaletas; Gramibiotic†; Graneodin; Graneodin N; Kenacomb; Nasomicina; Neo Coltirot; Neo Pelvicillin; Pantometil; Proetztotal; Austral.: Kenacomb; Neosporin; Otocomb Otic; Otodex; Sofradex; Soframycin; Austria: Mycostatin V; Topsym polyvalent; Volon A antibiotikahaltig; Belg.: Mycolog; Polyspectran Gramicidine; Braz.: Fonergin; Londerm-N; Mud; Neolon-D; Omcilon A M; Onciplus; Canad.: Antibiotic Cream†; Kenacomb†; Neosporin; Opticort; Optimyxin; Optimyxin Plus; Polycidin†; Polysporin; Polysporin Complete Antibiotic; Polysporin For Kids; Polysporin Plus Pain Relief; Polysporin Triple Antibiotic; Polytopic; ratio-Triacomb; Sofracort; Soframycin; Triacomb†; Viaderm-KC; Chile: Grifoftal†; Oftabiotico; Cz.: Sofradex†; Denm.: Kenalog Comp med Mycostatin; Sofradex; Fin.: Bafucin; Polysporin; Sofradex; Ger.: Polyspectran; Gr.: Kenacomb; Neo-Priphen; Hong Kong: Kenacomb; Neosporin; Polyoph; Sofradex; Triacomb; Hung.: Polyspor ; India: Kenacomb; Kenalog-S; Neosporin; Sofracort; Indon.: Blecidex; Isotic Enpigi; Neosyd; Sofradex; Irl.: Graneodin; Kenacomb; Neosporin†; Sofradex; Soframycin†; Israel: Dermacombin; Kenacomb†; Ital.: Eta Biocortilen VC; Vasosterone Antibiotico; Malaysia: Kenacomb; Pocin G; Sofradex; Mex.: Biotarson N; Biotarson O; Kenacomb; Neosporin; Nicobio†; Polixin; Poly-Micron; Septilisin; Sulned; Neth.: Mycolog; Polyspectran G†; Sofradex; Norw.: Sofradex; NZ: Kenacomb; Sofradex; Soframycin; Viaderm-KC; Philipp.: Kenacomb; Lidex NGN; Neosporin; Novasorin; Pol.: Dicortineff; Triacomb; Port.: Dropcina; Kenacomb; S.Afr.: Kenacomb; Neosporin†; Sofradex; Singapore: Kenacomb†; Sofradex; Spain: Flodermol; Fludronef; Intradermo Cort Ant Fung†; Midacina; Oftalmowell; Spectrocin†; Tivitis; Trigon Topico; Swed.: Bafucin; Switz.: Angidine; Mycolog N; Mycolog†; Neosporin; Sofradex; Topsym polyvalent; Tyrothricine + Gramicidine; Thai.: Dermacombin; Kenacomb; Neosporin†; Opsacin†; Polyoph; Sofradex; Topifram; Xanalin; Turk.: Neosporin; UAE: Panderm; UK: Graneodin†; Neosporin; Sofradex; Tri-Adcortyl; USA: Neosporin; Ocu-Spor-G; Ocutricin; Polymycin; Venez.: Kenacomb.
Published March 20, 2019.