Framycetin Sulfate

(rINNM)
Synonyms: Framicetino sulfatas; Framicetin-szulfát; Framycetin Sulphate tinsulfat; Framycetin-sulfát; Framysetiinisulfaatti; Neomycin B Sulphate; Sulfato de framicetina. 2-Deoxy-4O-(2,6-diamino-2,6dideoxyoxy
Cyrillic synonym: Фрамицетина Сульфат.

💊 Chemical information

Chemical formula: C23H46N6O13,xH2SO4.
CAS — 119-04-0 (framycetin); 4146-30-9 (framycetin sulfate).
ATC — D09AA01; R01AX08; S01AA07.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Framycetin Sulphate). A substance produced by growth of selected strains of Streptomyces fradiae or S. decaris or obtained by any other means. It contains not more than 3% of neomycin C and loses not more than 8% of its weight on drying. A white or yellowish-white, hygroscopic powder. The potency is not less than 630 units of neomycin B per mg, calculated with reference to the dried substance. Freely soluble in water; very slightly soluble in alcohol; practically insoluble in acetone. A 1% solution in water has a pH of 6.0 to 7.0. Store in airtight containers. Protect from light.

💊 Profile

Framycetin is an aminoglycoside antibiotic which forms the major component of neomycin and has similar actions and uses. Framycetin sulfate is used topically in usual concentrations of 1% for the treatment of infections of the skin, and in concentrations of 0.5% for infections of the eye and ear. It is often used with other antibacterials and corticosteroids in topical preparations. Framycetin sulfate is poorly absorbed from the gastrointestinal tract and has been given orally for the treatment of gastrointestinal infections and pre-operatively for bowel preparation. It has sometimes been given prophylactically as part of regimens for the selective decontamination of the digestive tract in patients in intensive care.

💊 Preparations

Proprietary Preparations

Austral.: Sofra-Tulle; Soframycin; Austria: Sofra-Tull; Belg.: Soframycine; Canad.: Sofra-Tulle; Soframycin; Fin.: Sofra-Tulle†; Ger.: Leukase N; SofraTull†; Hong Kong: Sofra-Tulle†; India: Sofra-Tulle; Soframycin; Indon.: Daryant-Tulle; Sofra-Tulle; Irl.: Soframycin; Israel: Sofra-Tulle†; Malaysia: Sofra-Tulle†; Norw.: Sofra-Tulle†; NZ: Soframycin; Rus.: Isofra (Изофра); S.Afr.: Sofra-Tulle; Soframycin; Singapore: Sofra-Tulle†; Switz.: Frakitacine†; Sofra-Tulle†; Soframycin; Thai.: Sofra-Tulle; UK: Sofra-Tulle; Soframycin†. Multi-ingredient: Arg.: Biotaer Nasal; Austral.: Otodex; Sofradex; Soframycin; Austria: Leukase; Leukase-Kegel; Belg.: Frakidex; Sofraline; Sofrasolone; Braz.: Fonergin; Canad.: Opticort; Proctol; Proctomyxin HC; Proctosedyl; ratio-Proctosone; Sofracort; Soframycin; Cz.: Pulpomixine; Septomixine; Sofradex†; Denm.: Proctosedyl; Sofradex; Fin.: Proctosedyl; Sofradex; Fr.: Corticetine; Frakidex; Framyxone; Novomyxine†; Polyfra; Ger.: Leukase N; Hong Kong: Frakidex; Frazoline; Proctosedyl†; Sofradex; India: Proctosedyl; Sofracort; Sofradex; Sofradex-F; Indon.: Sofradex; Irl.: Proctosedyl; Sofradex; Soframycin†; Malaysia: Proctosedyl; Sofradex; Neth.: Proctosedyl; Sofradex; Norw.: Proctosedyl; Sofradex; NZ: Sofradex; Soframycin; Philipp.: Proctosedyl; Pol.: Carident; Dexadent; Port.: Frakidex; S.Afr.: Proctosedyl; Sofradex; Singapore: Frakidex†; Proctosedyl; Sofradex; Spain: Abrasone; Aldo Otico†; Aldoderma; Nesfare; Otomidrin; Swed.: Proctosedyl†; Switz.: Corticetine†; Dexalocal-F; Frakidex; Septomixine; Sofradex; Thai.: Proctosedyl; Sofradex; Topifram; UK: Sofradex.
Published February 25, 2019.