Fleroxacin

(BAN, USAN, rINN)
Fleroxacin Chemical formula
Synonyms: AM-833; Fleroksasiini; Fléroxacine; Fleroxacino; Fleroxacinum; Ro-23-6240; Ro-23-6240/000. 6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid.
Cyrillic synonym: Флероксацин.

💊 Chemical information

Chemical formula: C17H18F3N3O3 = 369.3.
CAS — 79660-72-3.
ATC — J01MA08.
ATC Vet — QJ01MA08.

Pharmacopoeias.

In Chin.

💊 Profile

Fleroxacin is a fluoroquinolone antibacterial with actions and uses similar to those of ciprofloxacin, but is reported to have greater systemic bioavailability and a longer half-life. It is given orally for the treatment of susceptible infections in usual doses of 200 to 300 mg once daily. It has also been given by intravenous infusion. The incidence of adverse effects associated with fleroxacin has been relatively high.
1. Balfour JA, et al. Fleroxacin: a review of its pharmacology and therapeutic efficacy in various infections. Drugs 1995; 49: 794–850.

Adverse effects.

References to adverse effects associated with fleroxacin.
1. Bowie WR, et al. Adverse reactions in a dose-ranging study with a new long-acting fluoroquinolone, fleroxacin. Antimicrob Agents Chemother 1989; 33: 1778–82
2. Geddes AM. Safety of fleroxacin in clinical trials. Am J Med 1993; 94 (suppl 3A): 201S–203S
3. Kimura M, et al. Photosensitivity induced by fleroxacin. Clin Exp Dermatol 1996; 21: 46–7.

Breast feeding.

The American Academy of Pediatrics1 states that fleroxacin is usually compatible with breast feeding. However, in a study,2 in which women were given a single 400-mg dose and breast feeding was withheld for 48 hours, it was concluded that although a breast-fed infant would only receive a moderate amount (maximum 10 mg daily), fleroxacin should not be used in breast-feeding mothers due to the potential for adverse effects such as arthropathy in the infant.
1. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001; 108: 776–89. Correction. ibid.; 1029. Also available at: http://aappolicy.aappublications.org/cgi/content/full/ pediatrics%3b108/3/776 (accessed 26/05/04
2. Dan M, et al. Penetration of fleroxacin into breast milk and pharmacokinetics in lactating women. Antimicrob Agents Chemother 1993; 37: 293–6.

💊 Preparations

Proprietary Preparations

Ger.: Quinodis†; Jpn: Megalocin.
Published February 11, 2019.