Dihydrostreptomycin Sulfate

Dihydrostreptomycin Sulfate Chemical formula
Synonyms: Dihidrosztreptomicin-szulfát; Dihydrostreptomycin sulfát; Dihydrostreptomycin Sulphate fate de; Dihydrostreptomycini sulfas; Dihydrostreptomycinsulfat; Dihydrostreptomysiinisulfaatti; Sulfato de dihidroestreptomicina. O-2-Deoxy-2-methylaminooxy-3C-hydroxymethyl1 ,N 3 -diamidino
Cyrillic synonym: Дигидрострептомицина Сульфат.

💊 Chemical information

Chemical formula: (C21H41N7O12)2,3H2SO4 = 1461.4.
CAS — 128-46-1 (dihydrostreptomycin); 5490-27-7 (dihydrostreptomycin sulfate).
ATC — S01AA15.
ATC Vet — QS01AA15.


In Eur. and US, both for veterinary use only.

Ph. Eur. 6.2

(Dihydrostreptomycin Sulphate for Veterinary Use; Dihydrostreptomycin Sulphate BP(Vet) 2008). The sulfate of a substance obtained by catalytic hydrogenation of streptomycin or by any other means. The semi-synthetic product is derived from a fermentation product. Stabilisers may be added. A white or almost white, hygroscopic powder. It contains a maximum of 2.0% streptomycin sulfate calculated with reference to the dried drug. Freely soluble in water; practically insoluble in alcohol, in acetone, and in methyl alcohol. A 25% solution in water has a pH of 5.0 to 7.0. Store in airtight containers. Protect from light.

USP 31

(Dihydrostreptomycin Sulfate). A white or almost white amorphous or crystalline powder; the amorphous form is hygroscopic. Freely soluble in water; practically insoluble in acetone, in chloroform, and in methyl alcohol. pH of a solution in water containing the equivalent of dihydrostreptomycin 20% is between 4.5 and 7.0, except that if it is labelled as being solely for oral use, the pH is between 3.0 and 7.0. Store in airtight containers.

💊 Profile

Dihydrostreptomycin is an aminoglycoside antibacterial with actions similar to those of streptomycin. Since it is more likely than streptomycin to cause partial or complete loss of hearing it is not used parenterally in humans. It is not absorbed after oral doses, and has been given by this route for gastrointestinal infections. It is also used as the sulfate in veterinary medicine.

💊 Preparations

Proprietary Preparations

Spain: Citrocil. Multi-ingredient: Arg.: Gemipasmol†; Vagisan; Vagisan Compuesto; Mex.: Estrefen; Spain: Cilinafosal Dihidroestreptomicina; Estreptoenterol†; Salitanol Estreptomicina; Sulfintestin Neomicina.
Published February 03, 2019.