Chlortetracycline Hydrochloride

(BANM, rINNM)
Synonyms: Chlorotetracykliny chlorowodorek; Chlortetraciklino hidrochloridas; Chlortétracycline, chlorhydrate de; Chlortetracyclini hydrochloridum; Chlortetracyklin-hydrochlorid; Hidrocloruro de clortetraciclina; Klooritetrasykliinihydrokloridi; Klórtetraciklinhidroklorid; Klortetracyklinhydroklorid.
Cyrillic synonym: Хлортетрациклина Гидрохлорид.

💊 Chemical information

Chemical formula: C22H23ClN2O8,HCl = 515.3.
CAS — 64-72-2.
ATC — A01AB21; D06AA02; J01AA03; S01AA02. ATC Vet — QA01AB21; QD06AA02; QJ01AA03; QS01AA02.

Pharmacopoeias.

In Chin., Eur., Int., and US.

Ph. Eur. 6.2

(Chlortetracycline Hydrochloride). The hydrochloride of a substance produced by the growth of certain strains of Streptomyces aureofaciens or by any other means. A yellow powder. Slightly soluble in water and in alcohol; it dissolves in solutions of alkali hydroxides and carbonates. A 1% solution in water has a pH of 2.3 to 3.3. Protect from light.

USP 31

(Chlortetracycline Hydrochloride). A yellow, odourless crystalline powder. Soluble 1 in 75 of water and 1 in 560 of alcohol; practically insoluble in acetone, in chloroform, in dioxan, and in ether; soluble in solutions of alkali hydroxides and carbonates. pH of a 1% solution in water is between 2.3 and 3.3. Store in airtight containers. Protect from light.

💊 Profile

Chlortetracycline is a tetracycline derivative with general properties similar to those of tetracycline and is used as the hydrochloride, more often topically than orally. It is used as a 1% ophthalmic ointment and as a 3% ointment for application to the skin. It is poorly absorbed from the gastrointestinal tract compared with other tetracyclines but is sometimes given orally with other tetracycline derivatives.

💊 Preparations

BP 2008: Chlortetracycline Eye Ointment; Chlortetracycline Ointment; USP 31: Chlortetracycline Hydrochloride Ointment; Chlortetracycline Hydrochloride Ophthalmic Ointment.

Proprietary Preparations

Austria: Aureomycin; Belg.: Aureomycin; Aureomycine; Fr.: Aureomycine; Ger.: Aureomycin; Hong Kong: Aureomycin†; Chlortralim; Ital.: Aureomicina; Malaysia: Chlortralim; Norw.: Aureomycin†; Pol.: Chlorocyclinum; Port.: Aurecil†; Aureodermil†; Singapore: Chlortralim; Spain: Aureomicina; Dermosa Aureomicina; Thai.: Aureomycin; Chlortralim. Multi-ingredient: Austria: Aureocort; Braz.: Corciclen; Ger.: Aureodelf†; Aureomycin N†; Ital.: Aureocort; Aureomix; S.Afr.: Tr itet; UK: Aureocort; Deteclo†.
Published January 21, 2019.