Cethromycin

(USAN, rINN)
Synonyms: A-195773; Abbott-195773; ABT-773; Céthromycine; Cethromycinum; Cetromicina. (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4Ethyl-3a,7,9,11,13,15-hexamethyl-11-{[3-(quinolin-3-yl)prop-2enyl]oxy}-10-{[3,4,6-trideoxy-3-(dimethylamino)opyranosyl]oxy}octahydro-2H-oxacyclotetradecino[4,3d]oxazole-2,6,8,14(1H,7H,9H)-tetrone.
Cyrillic synonym: Цетромицин.

Chemical information

Chemical formula: C42H59N3O10 = 765.9.
CAS — 205110-48-1.

Profile

Cethromycin is a ketolide antibacterial under investigation for the treatment of susceptible respiratory-tract infections.
1. Dougherty TJ, Barrett JF. ABT-773: a new ketolide antibiotic. Expert Opin Invest Drugs 2001; 10: 343–51
2. Zhanel GG, et al. The ketolides: a critical review. Drugs 2002; 62: 1771–1804
3. Zhanel GG, et al. Ketolides: an emerging treatment for macrolide-resistant respiratory infections, focusing on S. pneumoniae. Expert Opin Emerg Drugs 2003; 8: 297–321
4. Reinert RR. Clinical efficacy of ketolides in the treatment of respiratory tract infections. J Antimicrob Chemother 2004; 53: 918–27
5. Anonymous. Cethromycin: A-195773, A-195773-0, A-1957730, Abbott-195773, ABT 773. Drugs R D 2007; 8: 95–102
6. Hammerschlag MR, Sharma R. Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections. Expert Opin Invest Drugs 2008; 17: 387–400.
Published January 18, 2019.