Cefotiam Hydrochloride

Cefotiam Hydrochloride Chemical formula
Synonyms: Abbott-48999; Céfotiam, Chlorhydrate de; Cefotiami Hydrochloridum; CGP-14221E (cefotiam or cefotiam hydrochloride); Hidrocloruro de cefotiam; SCE963. 7-[2-(2-Amino-1,3-thiazol4-yl)acetamido]-3-[1-(2dimethylaminoethyl)-1H-tetrazol-5ylthiomethyl]-3-cephem-4-carboxylic acid dihydrochloride.
Cyrillic synonym: Цефотиама Гидрохлорид.

💊 Chemical information

Chemical formula: C18H23N9O4S3,2HCl = 598.6.
CAS — 61622-34-2 (cefotiam); 66309-69-1 (cefotiam hydrochloride).
ATC — J01DC07.
ATC Vet — QJ0 1DC07.


In Jpn and US. Jpn also includes cefotiam hexetil hydrochloride.

USP 31

(Cefotiam Hydrochloride). Store in airtight containers.

💊 Profile

Cefotiam is a third-generation cephalosporin antibacterial with actions and uses similar to those of cefamandole. It is given intravenously or intramuscularly as the hydrochloride but doses are expressed in terms of the base; 1.14 g of cefotiam hydrochloride is equivalent to about 1 g of cefotiam. The usual dose is the equivalent of up to 6 g of cefotiam daily in divided doses, according to the severity of the infection. Cefotiam hexetil hydrochloride, a prodrug of cefotiam, is given orally in doses equivalent to 200 to 400 mg of cefotiam twice daily.
1. Brogard JM, et al. Clinical pharmacokinetics of cefotiam. Clin Pharmacokinet 1989; 17: 163–74.

💊 Preparations

USP 31: Cefotiam for Injection.

Proprietary Preparations

Austria: Spizef; Fr.: Taketiam; Texodil; Ger.: Spizef; Indon.: Aspil; Cefradol; Ceradolan; Ethidol; Fodiclo; Fotaram; Jpn: Pansporin; Philipp.: Ceradolan; Singapore: Ceradolan; Thai.: Ceradolan.
Published January 07, 2019.