Ceforanide

(BAN, USAN, rINN)
Ceforanide Chemical formula
Synonyms: BL-S786; Ceforanida; Céforanide; Ceforanidum. 7-[2-(α-Aminoo-tolyl)acetamido]-3-(1-carboxymethyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
Cyrillic synonym: Цефоранид.

💊 Chemical information

Chemical formula: C20H21N7O6S2 = 519.6.
CAS — 60925-61-3.
ATC — J01DC11.
ATC Vet — QJ01DC11.

Pharmacopoeias.

In US.

USP 31

(Ceforanide). A white to off-white powder. Practically insoluble in water, in chloroform, in ether, and in methyl alcohol; very soluble in 1N sodium hydroxide. pH of a 5% suspension in water is between 2.5 and 4.5. Store in airtight containers.

💊 Profile

Ceforanide is a second-generation cephalosporin antibacterial with actions and uses similar to those of cefamandole, although it is reported to be less active in vitro against some bacteria, including staphylococci and Haemophilus influenzae. It is used in the treatment of susceptible infections and for surgical infection prophylaxis. It is given as the lysine salt (C26H35N9O8S2= 665.7) but doses are expressed in terms of the equivalent amount of ceforanide; 1.28 g of ceforanide lysine is equivalent to about 1 g of ceforanide. It is given by deep intramuscular injection, or intravenously by slow injection over 3 to 5 minutes or by infusion. The usual adult dose is 1 to 2 g every 12 hours. Children may be given 20 mg/kg daily in 2 divided doses. For surgical infection prophylaxis, a dose of 1 to 2 g intravenously 1 hour before surgical incision is used in adults. Ceforanide contains a substituted N-methylthiotetrazole sidechain, a structure associated with hypoprothrombinaemia and alcohol intolerance. Probenecid does not affect the renal excretion of ceforanide.
1. Campoli-Richards DM, et al. Ceforanide: a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs 1987; 34: 411–37.

💊 Preparations

USP 31: Ceforanide for Injection.

Proprietary Preparations

Belg.: Precef†; Gr.: Radacef.
Published January 05, 2019.