Cefminox Sodium

(pINNM)
Cefminox Sodium Chemical formula
Synonyms: Cefminox sódico; Cefminox Sodique; MT-141; Natrii Cefminoxum. Sodium 7-{2-[(S)-2-amino-2-carboxyethyl]thioacetamido}7-methoxy-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem4-carboxylate.
Cyrillic synonym: Натрий Цефминокс.

💊 Chemical information

Chemical formula: C16H20N7NaO7S3 = 541.6.
CAS — 75481-73-1 (cefminox).

Pharmacopoeias.

Jpn includes the heptahydrate.

💊 Profile

Cefminox sodium is a cephamycin antibacterial with properties similar to those of cefoxitin but with an N-methylthiotetrazole side-chain like cefamandole. It is given intravenously as the sodium salt but doses are expressed in terms of cefminox; 1.04 g of cefminox sodium is equivalent to about 1 g of cefminox. A usual dose is 2 to 4 g daily given in divided doses.
1. Watanabe S, Omoto S. Pharmacology of cefminox, a new bactericidal cephamycin. Drugs Exp Clin Res 1990; 16: 461–7
2. Soriano F, et al. Comparative susceptibility of cefminox and cefoxitin to β-lactamases of Bacteroides spp. J Antimicrob Chemother 1991; 28: 55–60
3. Aguilar L, et al. Cefminox: correlation between in-vitro susceptibility and pharmacokinetics and serum bactericidal activity in healthy volunteers. J Antimicrob Chemother 1994; 33: 91–101
4. Mayama T, et al. Postmarketing surveillance on side-effects of cefminox sodium (Meicelin). Int J Clin Pharmacol Ther 1995; 33: 149–55
5. Hoellman DB, et al. In vitro activities of cefminox against anaerobic bacteria compared with those of nine other compounds. Antimicrob Agents Chemother 1998; 42: 495–501
6. Torres AJ, et al. Cefminox versus metronidazole plus gentamicin in intra-abdominal infections: a prospective randomized controlled clinical trial. Infection 2000; 28: 318–22.

Sodium content.

Each g of cefminox sodium contains about 1.84 mmol of sodium.

💊 Preparations

Proprietary Preparations

Jpn: Meicelin; Port.: Te n c e f ; Spain: Te n ce f; Thai.: Meicelin.
Published January 03, 2019.