Synonyms: Abbott-50192; Cefménoxime, Chlorhydrate de; Cefmenoxime Hemihydrochloride; Cefmenoximi Hydrochloridum; Hidrocloruro de cefmenoxima; SCE-1365 (cefmenoxime). (Z)-(7R)-7[2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid hydrochloride.
Cyrillic synonym: Цефменоксима Гидрохлорид.
💊 Chemical information
Chemical formula: (C16H17N9O5S3)2,HCl = 1059.6.
CAS — 65085-01-0 (cefmenoxime); 75738-58-8 (cefmenoxime hydrochloride).
ATC — J01DD05.
ATC Vet — QJ01DD05.
Pharmacopoeias.In Jpn and US.
USP 31(Cefmenoxime Hydrochloride). White to light orangeyellow crystals or crystalline powder. Very slightly soluble in water; practically insoluble in dehydrated alcohol and in ether; freely soluble in formamide; slightly soluble in methyl alcohol. Store in airtight containers.
Cefmenoxime is a third-generation cephalosporin antibacterial with actions and uses similar to those of cefotaxime. It has been given as the hydrochloride by intramuscular injection, or intravenously by injection or infusion in the treatment of susceptible infections. Like cefamandole, cefmenoxime has an N-methylthiotetrazole side-chain and coagulopathy and a disulfiram-like interaction with alcohol have been reported rarely. Cefmenoxime hydrochloride is also given as eye drops for the treatment of eye infections.
1. Campoli-Richards DM, Todd PA. Cefmenoxime: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 1987; 34: 188–221.
USP 31: Cefmenoxime for Injection.
Proprietary PreparationsGr.: Tacef†; Jpn: Bestcall; Bestron.
Published January 01, 2019.