Cefdinir

(BAN, USAN, rINN)
Cefdinir Chemical formula
Synonyms: Cefdinirum; CI-983; FK-482; Kefdiniiri. (−)-(6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7 2 -(Z)-oxime; 7-{(2-Amino-1,3-thiazol-4-yl)-2-[(Z)-hydroxyimino]acetamido}-3-vinylcephem-4-carboxylic acid.
Cyrillic synonym: Цефдинир.

💊 Chemical information

Chemical formula: C14H13N5O5S2 = 395.4.
CAS — 91832-40-5.
ATC — J01DD15.
ATC Vet — QJ01DD15.

Pharmacopoeias.

In Chin. and Jpn.

💊 Adverse Effects and Precautions

As for Cefalotin Sodium. There have been reports of reddish stools in patients given cefdinir with iron supplements (see also Interactions, below).

💊 Interactions

Absorption of cefdinir is decreased by antacids or iron supplements and doses should be separated by an interval of at least 2 hours. Probenecid reduces the renal excretion of cefdinir.

Iron.

A report1 of red stools in an infant given cefdinir whilst being fed with an infant formula containing supplemental iron. It was considered important to be aware of the interaction because of the risk that it might be mistaken for a sign of gastrointestinal bleeding.
1. Lancaster J, et al. Nonbloody, red stools from coadministration of cefdinir and iron-supplemented infant formulas. Pharmacotherapy 2008; 28: 678–81.

💊 Antimicrobial Action

As for Cefixime. However, cefdinir is reported to be much more active in vitro than cefixime against Staphylococcus aureus, but not meticillin-resistant strains, and it is less active against some Enterobacteriaceae.

💊 Pharmacokinetics

Cefdinir is absorbed from the gastrointestinal tract after oral doses, peak plasma concentrations occurring 2 to 4 hours after a dose. Oral bioavailability has been estimated to range from 16 to 25%. It is widely distributed into tissues and is 60 to 70% bound to plasma proteins. Cefdinir is not appreciably metabolised and is excreted in the urine with an elimination half-life of 1.7 hours. Cefdinir is removed by dialysis.

💊 Uses and Administration

Cefdinir is a third-generation oral cephalosporin antibacterial with actions and uses similar to those of cefixime. It is given orally in a usual adult dose of 600 mg daily as a single dose or in two divided doses. Children may be given 14 mg/kg daily up to a maximum of 600 mg daily. Doses may need to be reduced in patients with renal impairment (see below).
1. Guay DRP. Cefdinir: an expanded-spectrum oral cephalosporin. Ann Pharmacother 2000; 34: 1469–77
2. Guay DR, et al. Cefdinir: an advanced-generation, broad-spectrum oral cephalosporin. Clin Ther 2002; 24: 473–89
3. Perry CM, Scott LJ. Cefdinir: a review of its use in the management of mild-to-moderate bacterial infections. Drugs 2004; 64: 1433–64
4. Sader HS, Jones RN. Cefdinir: an oral cephalosporin for the treatment of respiratory tract infections and skin and skin structure infections. Expert Rev Anti Infect Ther 2007; 5: 29–43. Correction. ibid.; 754. [dose error]

Administration in renal impairment.

Doses of cefdinir should be reduced to 300 mg once daily in patients with renal impairment whose creatinine clearance is less than 30 mL/minute.

💊 Preparations

Proprietary Preparations

India: Kefnir†; Sefdin; Jpn: Cefzon; Mex.: Omnicef; Thai.: Omnicef; USA: Omnicef.
Published December 27, 2018.