Alatrofloxacin Mesilate

(rINNM)
Alatrofloxacin Mesilate Chemical formula
Synonyms: Alatrofloxacin Mesylate (USAN); Alatrofloxacine, Mésilate d’; Alatrofloxacini Mesilas; CP-116517-27; Mesilato de alatrofloxacino. 7-{(1R,5S,6s)-6-[(S)-2-((S)-2-Aminopropionamido)propionamido]-3-azabicyclo[3.1.0]hex-3-yl}-1-(2,4-difluorophenyl)-6-fluoro1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid monomethanesulphonate.
Cyrillic synonym: Алатрофлоксацина Мезилат.

💊 Chemical information

Chemical formula: C26H25F3N6O5,CH3SO3H = 654.6.
CAS — 157182-32-6 (alatrofloxacin); 157605-25-9 (alatrofloxacin mesilate).

💊 Profile

Alatrofloxacin is a prodrug of the fluoroquinolone antibacterial trovafloxacin and has been used intravenously as the mesilate in the treatment of susceptible infections. Alatrofloxacin and trovafloxacin preparations were withdrawn worldwide after reports of unpredictable severe hepatic adverse effects, including some fatalities.

💊 Preparations

Proprietary Preparations

Canad.: Trovan†; USA: Trovan†.
Published October 10, 2018.