Enoxolone

(BAN, rINN)
Enoxolone Chemical formula
Synonyms: Enoksolonas; Enoksoloni; Enoxolon; Enoxolona; Énoxolone; Enoxolonum; Glycyrrhetic Acid; Glycyrrhetinic Acid; Kwas glicyryzynowy. 3
Cyrillic synonym: Эноксолон.

💊 Chemical information

Chemical formula: C30H46O4 = 470.7.
CAS — 471-53-4.
ATC — D03AX10.
ATC Vet — QD03AX10.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Enoxolone). A white or almost white, crystalline powder. It exhibits polymorphism. Practically insoluble in water; soluble in dehydrated alcohol; sparingly soluble in dichloromethane. Protect from light.

💊 Profile

Enoxolone is a complex triterpene prepared from glycyrrhizic acid, a constituent of liquorice. Enoxolone is used locally in preparations for the treatment of non-infective inflammatory disorders of the skin, mouth, throat, and rectum. Enoxolone potassium (potassium glycyrrhetinate) has been used similarly. Derivatives of enoxolone, including its aluminium salt and carbenoxolone have been used in the treatment of benign peptic ulcer disease and other gastrointestinal disorders. Whether this also increased the systemic absorption and toxicity of hydrocortisone was unclear.2 However, for reference to adverse effects attributed to systemic inhibition of cortisol when enoxolone (glycyrrhetinic acid) is produced during metabolism of ingested liquorice, see Effects on Fluid and Electrolyte Homoeostasis. A cream containing enoxolone with hyaluronic acid, telmesteine, and a grape extract, has been investigated with apparent benefit in the management of mild to moderate eczema.3,4 However, topical application of enoxolone has been associated with contact dermatitis.5
1. Teelucksingh S, et al. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 1990; 335: 1060–3
2. Greaves MW. Potentiation of hydrocortisone activity in skin by glycerrhetinic acid. Lancet 1990; 336: 876
3. Belloni G, et al. A randomised, double-blind, vehicle-controlled study to evaluate the efficacy and safety of MAS063D (Atopiclair) in the treatment of mild to moderate atopic dermatitis. Eur J Dermatol 2005; 15: 31–6
4. Abramovits W, Boguniewicz M. Adult Atopiclair Study Group. A multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild to moderate atopic dermatitis in adults. J Drugs Dermatol 2006; 5: 236–44
5. Tanaka S, et al. Allergic contact dermatitis from enoxolone. Contact Dermatitis 2001; 44: 192.

💊 Preparations

Proprietary Preparations

Belg.: Dermanox; Fr.: Arthrodont; Moustidose; PO 12; S.Afr.: Arthrodont. Multi-ingredient: Arg.: Anastim con RTH; Empecid Pie; Chile: Gingilacer†; Ruboril; Sebium AKN; Suavigel; Fr.: Apaisance; Erygine; Fluocaril dents sensibles; Hexalyse; Hyseke; Hyseke Solaire; Mousticologne; Moustidose Bebe-Nourrisson; Night Peel; Novophane; Novophane S; Photoderm Flush†; Photoderm Laser†; Pyreflor; Sebium AKN; Sedorrhoide; Tiq’Aouta; Vocadys; Hong Kong: Hexalyse; Indon.: Polik; Israel: Aphtagone; ApthaX; Gelclair†; Ital.: Acnesan†; Bactilene; Benodent Gel Gengivale†; Biothymus DS; Eudent con Glysan†; Fluocaril; Lenipasta†; Lenirose†; Lisomucil Gola; Neo-Stomygen; Pastiglie Valda†; Prurex; Skab 2; Viderm†; Mex.: Angenovag; Periodentyl; Port.: Despigmentante; Rus.: Hexalyse (Гексализ); Spain: Angileptol; Anginovag; Roberfarin; UK: Atopiclair; Gelclair; Xclair; USA: Atopiclair; Gelclair; Venez.: Sebium AKN; Sensibio DS.
Published January 03, 2019.